Novavax’ saponin-based Matrix-M improves immune responses and enables vaccine dose-sparing. Matrix-M adjuvant is a valuable component of vaccine development, providing multiple immune system enhancements, a well-understood mechanism of action, and robust clinical experience where it was shown to be well tolerated in human studies to date.

Link: https://chiefio.wordpress.com/2021/09/16/novavax-is-it-new-enough-moths-between-you-and-mrna/