{"id":1444470,"date":"2023-12-18T04:20:00","date_gmt":"2023-12-18T09:20:00","guid":{"rendered":"https:\/\/bugaluu.com\/news\/?p=1444470"},"modified":"2023-12-18T04:20:00","modified_gmt":"2023-12-18T09:20:00","slug":"nobel-prize-winner-seeking-to-cure-cancer-with-mrna-technology","status":"publish","type":"post","link":"https:\/\/bugaluu.com\/news\/nobel-prize-winner-seeking-to-cure-cancer-with-mrna-technology\/1444470\/","title":{"rendered":"Nobel Prize Winner Seeking to Cure Cancer With mRNA Technology"},"content":{"rendered":"

Nobel Prize Winner Seeking to Cure Cancer With mRNA Technology<\/span><\/p>\n

\n

Authored by Naveen Athrappully via The Epoch Times<\/a> (emphasis ours),<\/em><\/p>\n

Nobel Prize winner Dr. Drew Weissman talked recently about using mRNA technology to prevent the development of cancers among vulnerable people.<\/strong><\/p>\n

Japan Prize 2022 Laureates Hungarian-American biochemist Katalin Kariko (L) and American physician-scientist Drew Weissman pose with their trophy during the Japan Prize presentation ceremony in Tokyo on April 13, 2022. (Eugene Hoshiko \/Pool\/AFP via Getty Images)<\/em><\/a><\/p>\n

Dr. Weissman suggested using mRNA vaccines to prevent cancers during his Nobel Prize lecture<\/a> on Dec. 7. \u201cThe idea here is that you treat people before they develop cancer,<\/strong>\u201d he said<\/a>. Dr. Weissman won the Nobel Prize for medicine this year along with Dr. Katalin Karik\u00f3 for developing a method<\/a> to prevent the immune system from launching inflammatory attacks when lab-made mRNA is injected into the body, thus enabling the therapeutic use<\/a> of the medical technology.<\/p>\n

This allowed for the rapid development of mRNA COVID-19 vaccines. Dr. Weissman and his team at the University of Pennsylvania are now focusing on using mRNA technology to treat cancer.<\/p>\n

A vaccine under development by the team teaches the body to identify and fight tumor cells. The vaccine is aimed at people who have a genetic mutation which raises their risk of cancer.<\/p>\n

For instance, BRCA is a gene that contributes to breast cancer risk. Out of the more than 18 million cancers identified globally every year, around five to 10 percent stem from genetic mutations.<\/strong><\/p>\n

The Nobel Prize winner and his team investigated methods to use mRNA to trigger an immune response in the body that would kill cancer cells.<\/p>\n

In experiments with mice, the researchers injected mRNA that taught the body to produce a protein called IL-12. This protein directs the body to produce immune cells called effector T-cells that can remove cancer.<\/p>\n

\u201cWe know that it’s five or 10 years that cancer cells first start to appear before you’ve got full-fledged large tumors that impair function<\/strong>,\u201d Dr. Weissman said<\/a> during his lecture.<\/p>\n

\u201cIf we treat these people, maybe every 5 years, with a vaccine that only makes effector T-cells, [it] will clean out, clear away, kill all of the transformed cells and maybe completely prevent cancer from ever appearing in these patients<\/strong>.\u201d<\/p>\n

mRNA Treatments<\/h2>\n

Many pharma companies are already researching the use of mRNA for cancer therapy. This month, Moderna and Merck & Co. announced that they have begun a late-stage trial of their experimental personalized mRNA treatment for patients with a type of lung cancer.<\/p>\n

The therapy, called v940, will be tailored for each patient individually to trigger T-cells. It will be offered in combination with the drug Keytruda. In July, the two companies kicked off a late-stage study of the combination therapy in patients with melanoma, a skin cancer.<\/p>\n

Earlier this year, BioNTech, the company that partnered with Pfizer to make the COVID-19 mRNA vaccines, said that it had signed a deal with the UK government for personalized cancer therapies.<\/p>\n

According to the deal, up to 10,000 patients will be enrolled in clinical trials by the end of 2030<\/strong>. The cancer therapies will use mRNA technology in their treatments.<\/p>\n

In addition to cancer, mRNA technology is being investigated for use in the treatment<\/a> of allergies, genetic diseases, heart attack, stroke, heart failure, neurodevelopmental disorders, HIV, malaria, and tuberculosis.<\/p>\n

Developing mRNA to vaccinate against other diseases when the existing technology has considerable flaws brings up several safety questions.<\/p>\n

Researchers in a landmark new study<\/a> have discovered a sequence within the Pfizer mRNA COVID vaccine that produces an \u201cunintended immune response\u201d in the body, which experts are calling a massive \u201cdevelopmental and regulatory failure.\u201d<\/p>\n

Synthetic Messenger Ribonucleic Acid (mRNA), such as that used in Moderna and Pfizer vaccines, enables the body to create a specific spike protein mimicking SARS-CoV-2. The body reacts to the foreign protein and generates protective immunity, which theoretically neutralizes the real virus when it enters the body.<\/p>\n

\u201cResearchers from the Medical Research Council (MRC) Toxicology Unit have discovered that the cellular machinery that \u2018reads\u2019 mRNAs \u2018slips\u2019 when confronted with repeats of a chemical modification commonly found in mRNA therapeutics<\/strong>. In addition to the target protein, these slips lead to the production of \u2018off-target\u2019 proteins triggering an unintended immune response,\u201d said a press release for the study published in Nature on Dec. 6.<\/p>\n

Last week, Florida Surgeon General Dr. Joseph Ladapo demanded that federal health officials provide<\/a> more info on the discovery of DNA fragments in Pfizer and Moderna COVID-19 vaccines \u201chitchhiking into human cells.\u201d<\/p>\n

In a letter to officials at the CDC and the U.S. Food and Drug Administration (FDA), he pointed out that the presence of Simian Virus 40 (SV40) promoter\/enhancer DNA in the vaccines poses a \u201cheightened risk of DNA integration into host cells.\u201d<\/p>\n

\u201cDNA integration could theoretically impact a human\u2019s oncogenes\u2014the genes which can transform a healthy cell into a cancerous cell<\/strong>,\u201d he warned.<\/p>\n

There is also research<\/a> showing that COVID-19 mRNA vaccines can reduce a beneficial gut bacteria called Bifidobacteria, the presence of which is associated with higher immunity against pathogens and cancer.<\/p>\n<\/div>\n

Tyler Durden<\/a><\/span>
\nSun, 12\/17\/2023 – 23:20<\/span><\/p>\n

\u200bhttps:\/\/www.zerohedge.com\/markets\/nobel-prize-winner-seeking-cure-cancer-mrna-technology<\/a>\u00a0<\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

Nobel Prize Winner Seeking to Cure Cancer With mRNA Technology Authored by Naveen Athrappully via The Epoch Times (emphasis ours), Nobel Prize winner Dr. Drew…<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1444470","post","type-post","status-publish","format-standard","hentry","category-news","wpcat-1-id"],"_links":{"self":[{"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/posts\/1444470","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/comments?post=1444470"}],"version-history":[{"count":0,"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/posts\/1444470\/revisions"}],"wp:attachment":[{"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/media?parent=1444470"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/categories?post=1444470"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/tags?post=1444470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}