{"id":1473066,"date":"2024-06-24T17:45:00","date_gmt":"2024-06-24T21:45:00","guid":{"rendered":"https:\/\/bugaluu.com\/news\/?p=1473066"},"modified":"2024-06-24T17:45:00","modified_gmt":"2024-06-24T21:45:00","slug":"breakthrough-eli-lilly-weight-loss-drug-data-to-treat-obesity-sleep-apnea-sends-cpap-device-makers-plunging","status":"publish","type":"post","link":"https:\/\/bugaluu.com\/news\/breakthrough-eli-lilly-weight-loss-drug-data-to-treat-obesity-sleep-apnea-sends-cpap-device-makers-plunging\/1473066\/","title":{"rendered":"“Breakthrough” Eli Lilly Weight-Loss Drug Data To Treat Obesity & Sleep Apnea, Sends CPAP Device-Makers Plunging"},"content":{"rendered":"

“Breakthrough” Eli Lilly Weight-Loss Drug Data To Treat Obesity & Sleep Apnea, Sends CPAP Device-Makers Plunging<\/span><\/p>\n

\n

Shares of medical equipment companies specializing in sleep apnea treatments nosedived on Monday after a new study from\u00a0Eli Lilly and Company revealed that its tirzepatide weight-loss drug\u00a0significantly reduced\u00a0the severity of sleep apnea.\u00a0<\/p>\n

On Friday,\u00a0Eli Lilly announced<\/a> new results from its\u00a0SURMOUNT-OSA phase 3 clinical trials evaluating tirzepatide\u00a0injection to treat\u00a0moderate-to-severe obstructive sleep apnea, otherwise known as OSA.\u00a0<\/p>\n

<\/a><\/p>\n

Tirzepatide, branded as Mounjaro (a diabetes drug) and Zepbound (a weight loss drug), reduced\u00a0moderate-to-severe OSA in obese adults with and without positive airway pressure (PAP) therapy.\u00a0<\/p>\n

Eli Lilly and Company (NYSE: LLY) announced detailed results from the SURMOUNT-OSA <\/em>phase 3 clinical trials evaluating tirzepatide injection (10 mg or 15 mg)<\/em><\/strong> for the treatment of moderate-to-severe obstructive sleep apnea (OSA) in adults with obesity, <\/em>with and without positive airway pressure (PAP) therapy<\/em><\/strong>. <\/em><\/p>\n

In both studies, <\/em>tirzepatide achieved all primary and key secondary endpoints<\/em><\/strong> for both the efficacy and treatment-regimenii estimands and demonstrated a <\/em>mean reduction of up to 62.8% on the apnea-hypopnea index (AHI), or about 30 fewer events restricting or blocking a person’s airflow per hour of sleep, compared to placebo.<\/em><\/strong><\/p>\n

“In the trials, patients with moderate-to-severe obstructive sleep apnea and obesity treated with tirzepatide experienced about 30 fewer disruptive events every hour of sleep and nearly half achieved disease resolution<\/strong>,” said Atul Malhotra, MD, Peter C. Farrell presidential chair, professor of medicine at University of California San Diego School of Medicine and director of sleep medicine at UC San Diego Health.<\/p>\n

Malhotra continued,\u00a0“OSA can be very disruptive to daily life and affects a person’s long-term health when left untreated because it can lead to serious cardiometabolic complications. These data support the efficacy of tirzepatide in adults living with moderate-to-severe OSA and obesity and has the potential to add to our toolbox for OSA treatment<\/strong>.”\u00a0<\/p>\n

Louis Aronne, an obesity specialist at Weill Cornell Medicine, told Bloomberg that\u00a0Eli Lilly’s\u00a0phase 3 clinical data of tirzepatide is a “breakthrough” for the “treatment of obesity and sleep apnea.”\u00a0\u00a0<\/strong><\/p>\n

In markets,\u00a0Eli Lilly’s shares rose 2% by the early afternoon trade in the US.\u00a0BofA analysts noted earlier that the magnitude of OSA resolution from tirzepatide treatment “was not baked into investors’ expectations,” with the firm maintaining a ‘Buy’ rating and $1,000 price target.\u00a0<\/p>\n

<\/a><\/p>\n

Meanwhile,\u00a0Citi analysts\u00a0downgraded ResMed, which makes breathing machines known as CPAP devices, to ‘Neutral’ from ‘Buy’ on the\u00a0tirzepatide development. Shares on Monday of\u00a0ResMed plunged 15%, along with\u00a0Inspire Medical Systems -17% and\u00a0AdaptHealth -11.5%<\/p>\n

<\/a><\/p>\n

Citi analysts also said the data\u00a0indicates that GLP-1 is a viable treatment option for the 70% of OSA patients who are obese.\u00a0<\/p>\n<\/div>\n

Tyler Durden<\/a><\/span>
\nMon, 06\/24\/2024 – 13:45<\/span><\/p>\n

\u200bhttps:\/\/www.zerohedge.com\/markets\/breakthrough-eli-lilly-weight-loss-drug-data-treat-obesity-sleep-apnea-sends-c-pap-device<\/a>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

“Breakthrough” Eli Lilly Weight-Loss Drug Data To Treat Obesity & Sleep Apnea, Sends CPAP Device-Makers Plunging Shares of medical equipment companies specializing in sleep apnea…<\/p>\n","protected":false},"author":0,"featured_media":1473067,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1],"tags":[],"class_list":["post-1473066","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","wpcat-1-id"],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pbimBl-6bd8","jetpack_featured_media_url":"https:\/\/bugaluu.com\/news\/wp-content\/uploads\/sites\/3\/2024\/06\/2024-06-24_13-27-58-ORdIoF.png","_links":{"self":[{"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/posts\/1473066","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/comments?post=1473066"}],"version-history":[{"count":0,"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/posts\/1473066\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/media\/1473067"}],"wp:attachment":[{"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/media?parent=1473066"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/categories?post=1473066"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/tags?post=1473066"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}