{"id":1484170,"date":"2024-08-16T23:15:00","date_gmt":"2024-08-17T03:15:00","guid":{"rendered":"https:\/\/bugaluu.com\/news\/?p=1484170"},"modified":"2024-08-16T23:15:00","modified_gmt":"2024-08-17T03:15:00","slug":"aging-is-not-a-gradual-process-but-accelerates-at-2-main-stages","status":"publish","type":"post","link":"https:\/\/bugaluu.com\/news\/aging-is-not-a-gradual-process-but-accelerates-at-2-main-stages\/1484170\/","title":{"rendered":"Aging Is Not A Gradual Process, But Accelerates At 2 Main Stages"},"content":{"rendered":"

Aging Is Not A Gradual Process, But Accelerates At 2 Main Stages<\/span><\/p>\n

\n

Authored by Cara Michelle Miller via The Epoch Times<\/a> (emphasis ours),<\/em><\/p>\n

Aging has traditionally been viewed synonymously with a steady decline in health, but recent research unveils a more complex picture.<\/strong><\/p>\n

Aging is not gradual but surges at key stages of life, particularly during our 40s and 60s, due to dramatic shifts in our molecules and microorganisms, according to researchers at Stanford Medicine, who published a study on Wednesday in Nature Aging.<\/p>\n

(PeopleImages.com – Yuri A\/Shutterstock)<\/em><\/a><\/p>\n

The researchers analyzed how biomarkers\u2014molecules such as RNA and proteins that reflect biological changes\u2014shift across distinct five-year intervals in people aged 25 to 75 and beyond.<\/strong><\/p>\n

Unlike standard medical evaluations, which might involve only 15 to 20 measurements, the researchers made \u201ctens of thousands of measurements.\u201d They found that biomarkers change most dramatically during two key periods in our lives: the mid-40s and the early 60s.<\/p>\n

The researchers found it interesting to find observable changes related to cardiovascular disease and other health issues. This is important because acknowledging such changes can lead to actionable steps for improvement, Michael Snyder, who holds a doctorate in biology and is the chair of genetics and the study\u2019s senior author, told The Epoch Times.<\/p>\n

He added that understanding these specific periods of change could help in developing interventions.<\/p>\n

2 Key Periods of Change<\/h2>\n

The researchers followed thousands of molecules and microbes in their investigation. About 81 percent of the molecules exhibited significant nonlinear changes, meaning they changed more at certain ages than others.<\/strong> Only around 7 percent changed at a constant rate as study participants aged.<\/p>\n

The study<\/a> tracked participants over periods ranging from two to seven years. Previous findings from this same group of volunteers showed that people\u2019s kidneys, livers, metabolisms, and immune systems aged at different rates.<\/p>\n

The researchers analyzed 5,405 samples from 108 participants, encompassing more than 135,000 biological features, including gene activity, proteins, metabolites, and microbiomes. This culminated in a total of nearly 250 billion distinct data points.<\/p>\n

When the researchers analyzed clusters of molecules showing the most significant changes, they identified two critical periods: the mid-40s and early 60s, during which these transformations were most pronounced.<\/p>\n

Around age 40, the following was observed:<\/strong><\/p>\n

Changes in molecules indicated a reduced efficiency in alcohol, caffeine, and fat metabolism.
\n\tThe risk of cardiovascular diseases increased as platelets and proteins involved in blood clotting became impaired.
\n\tSkin cells and proteins became dysregulated, potentially impairing skin structure and elasticity.<\/p>\n

The following occurred around age 60:<\/strong><\/p>\n

Molecular changes indicated further reduced efficiency in metabolizing caffeine and essential fatty acids. Unsaturated fat production also decreased.
\n\tGlucose metabolism was affected, suggesting elevated insulin resistance.
\n\tKidney function declined, as indicated by higher blood urea nitrogen levels, which show the kidneys are becoming less effective at filtering waste from the body.
\n\tCardiac issues increased due to a rise in plasma levels of phenylalanine, an essential amino acid associated with heart problems.
\n\tHigher levels of cytokines, proteins that regulate the immune system, showed that the immune system weakens.<\/p>\n

For those in their 60s, monitoring kidney function and increasing water intake could be beneficial, Snyder suggested.<\/p>\n

Similarly, individuals in their 40s should heed changes in lipid metabolism and consider cutting back on fatty meals. Snyder pointed out that these insights underline the importance of recognizing and addressing biological changes to manage health effectively as we age.<\/p>\n

Overall, people in both age groups should consider exercising more to support heart health and preserve muscle mass. In one\u2019s 40s, it\u2019s also a good idea to drink less alcohol since the body doesn\u2019t metabolize it as well anymore, added Snyder.<\/strong><\/p>\n

The major changes seen in people\u2019s mid-40s surprised Snyder and his team.<\/p>\n

\u201cI don\u2019t know that I would have necessarily known that there\u2019d be such a big period of change [in] people at their mid-40s,\u201d said Snyder.<\/p>\n

The researchers first thought that menopause or perimenopause might be causing these changes in women and affecting the overall results. However, when they looked at the data separately for men and women, they found that men in their mid-40s experienced similar changes.<\/strong> \u201c[In women, people might think] maybe it\u2019s all due to women hitting menopause,\u201d Synder said. \u201cBut it turns out the same thing\u2019s there, whether it\u2019s male or female.\u201d<\/p>\n

\u201cThis suggests that while menopause or perimenopause may contribute to the changes observed in women in their mid-40s, there are likely other, more significant factors influencing these changes in both men and women,\u201d study first author Xiaotao Shen, who has a doctorate in metabolomics and bioinformatics and is a former Stanford Medicine postdoctoral scholar, said in a press release<\/a>. \u201cIdentifying and studying these factors should be a priority for future research.\u201d<\/p>\n

Personalized Medicine: Informing Lifestyle Choices<\/h2>\n

The research team plans to explore the drivers of these clusters of change. Such changes point to the need for people to pay attention to their health, especially in their 40s and 60s, the researchers said.<\/p>\n

Snyder, who is also the author of the book \u201cGenomics and Personalized Medicine: What Everyone Needs to Know,\u201d said that the study is a step toward moving beyond generic advice like \u201cexercise more\u201d or \u201ceat better\u201d and creating personalized aging profiles that pinpoint exact health risks.<\/p>\n

\u201dBy understanding these patterns … you can take action on it<\/strong>,\u201d he added.<\/p>\n<\/div>\n

Tyler Durden<\/a><\/span>
\nFri, 08\/16\/2024 – 19:15<\/span><\/p>\n

\u200bhttps:\/\/www.zerohedge.com\/medical\/aging-not-gradual-process-accelerates-2-main-stages<\/a>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

Aging Is Not A Gradual Process, But Accelerates At 2 Main Stages Authored by Cara Michelle Miller via The Epoch Times (emphasis ours), Aging has…<\/p>\n","protected":false},"author":0,"featured_media":1484171,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1484170","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","wpcat-1-id"],"_links":{"self":[{"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/posts\/1484170","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/comments?post=1484170"}],"version-history":[{"count":0,"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/posts\/1484170\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/media\/1484171"}],"wp:attachment":[{"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/media?parent=1484170"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/categories?post=1484170"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bugaluu.com\/news\/wp-json\/wp\/v2\/tags?post=1484170"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}