The Home Depot North 281 Store in San Antonio, TX 78258

Mon-Sat: 6:00am – 10:00pm. Sun: 8:00am – 8:00pm. Curbside: 09:00am – 6:00pm. Location. 20740 Us Hwy 281 North. San Antonio, TX 78258. Local Ad. Directions. Curbside Pickup with The Home Depot App Order online, check in with the app, and we’ll bring the items out to your vehicle.

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