pick-me-up (pĭk′mē-ŭp′) n. Informal A drink, often an alcoholic beverage, taken as a stimulant or a cure for a hangover. pick-me-up n informal a tonic or restorative, esp a special drink taken as a stimulant pick′-me-up` n. 1. something, as a drink or snack, taken to restore one’s energy or good spirits. 2. any restorative. [1865–70 …