Prescription-strength treatments for GERD include: Prescription-strength H-2-receptor blockers. These include prescription-strength famotidine (Pepcid) and nizatidine. These medications are generally well-tolerated but long-term use may be associated with a slight increase in risk of vitamin B-12 deficiency and bone fractures.
https://www.mayoclinic.org/diseases-conditions/gerd/diagnosis-treatment/drc-20361959

