Penn State vs. Indiana Betting Trends. Note: All trends date back to the start of the 2005 season, unless otherwise noted. Why Backing Penn State is a Good Bet. Series Dominance. Penn State has dominated this series with a 21-1 straight up record. Since the 2007 season, the Nittany Lions are 10-1 over the Hoosiers (though they are only 5-6-1 ATS).

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