Tazemetostat in advanced epithelioid sarcoma with loss of …

January 27, 2021

Epithelioid sarcoma is a rare and aggressive soft-tissue sarcoma subtype. Over 90% of tumours have lost INI1 expression, leading to oncogenic dependence on the transcriptional repressor EZH2. In this study, we report the clinical activity and safety of tazemetostat, an oral selective EZH2 inhibitor, in patients with epithelioid sarcoma.

https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(20)30451-4/fulltext

Tazemetostat in advanced epithelioid sarcoma with loss of … <body> <h1> Array ( [0] => razemetostat in advanced epithelioid sarcoma with loss of … [1] => fazemetostat in advanced epithelioid sarcoma with loss of … [2] => gazemetostat in advanced epithelioid sarcoma with loss of … [3] => yazemetostat in advanced epithelioid sarcoma with loss of … [4] => 6azemetostat in advanced epithelioid sarcoma with loss of … [5] => 5azemetostat in advanced epithelioid sarcoma with loss of … [6] => tzzemetostat in advanced epithelioid sarcoma with loss of … [7] => tszemetostat in advanced epithelioid sarcoma with loss of … [8] => twzemetostat in advanced epithelioid sarcoma with loss of … [9] => tqzemetostat in advanced epithelioid sarcoma with loss of … [10] => taxemetostat in advanced epithelioid sarcoma with loss of … [11] => tasemetostat in advanced epithelioid sarcoma with loss of … [12] => taaemetostat in advanced epithelioid sarcoma with loss of … [13] => tazwmetostat in advanced epithelioid sarcoma with loss of … [14] => tazsmetostat in advanced epithelioid sarcoma with loss of … [15] => tazdmetostat in advanced epithelioid sarcoma with loss of … [16] => tazrmetostat in advanced epithelioid sarcoma with loss of … [17] => taz4metostat in advanced epithelioid sarcoma with loss of … [18] => taz3metostat in advanced epithelioid sarcoma with loss of … [19] => tazenetostat in advanced epithelioid sarcoma with loss of … [20] => tazeketostat in advanced epithelioid sarcoma with loss of … [21] => tazejetostat in advanced epithelioid sarcoma with loss of … [22] => tazemwtostat in advanced epithelioid sarcoma with loss of … [23] => tazemstostat in advanced epithelioid sarcoma with loss of … [24] => tazemdtostat in advanced epithelioid sarcoma with loss of … [25] => tazemrtostat in advanced epithelioid sarcoma with loss of … [26] => tazem4tostat in advanced epithelioid sarcoma with loss of … [27] => tazem3tostat in advanced epithelioid sarcoma with loss of … [28] => tazemerostat in advanced epithelioid sarcoma with loss of … [29] => tazemefostat in advanced epithelioid sarcoma with loss of … [30] => tazemegostat in advanced epithelioid sarcoma with loss of … [31] => tazemeyostat in advanced epithelioid sarcoma with loss of … [32] => tazeme6ostat in advanced epithelioid sarcoma with loss of … [33] => tazeme5ostat in advanced epithelioid sarcoma with loss of … [34] => tazemetistat in advanced epithelioid sarcoma with loss of … [35] => tazemetkstat in advanced epithelioid sarcoma with loss of … [36] => tazemetlstat in advanced epithelioid sarcoma with loss of … [37] => tazemetpstat in advanced epithelioid sarcoma with loss of … [38] => tazemet0stat in advanced epithelioid sarcoma with loss of … [39] => tazemet9stat in advanced epithelioid sarcoma with loss of … [40] => tazemetoatat in advanced epithelioid sarcoma with loss of … [41] => tazemetoztat in advanced epithelioid sarcoma with loss of … [42] => tazemetoxtat in advanced epithelioid sarcoma with loss of … [43] 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epi6helioid sarcoma with loss of … [131] => tazemetostat in advanced epi5helioid sarcoma with loss of … [132] => tazemetostat in advanced epitgelioid sarcoma with loss of … [133] => tazemetostat in advanced epitbelioid sarcoma with loss of … [134] => tazemetostat in advanced epitnelioid sarcoma with loss of … [135] => tazemetostat in advanced epitjelioid sarcoma with loss of … [136] => tazemetostat in advanced epituelioid sarcoma with loss of … [137] => tazemetostat in advanced epityelioid sarcoma with loss of … [138] => tazemetostat in advanced epithwlioid sarcoma with loss of … [139] => tazemetostat in advanced epithslioid sarcoma with loss of … [140] => tazemetostat in advanced epithdlioid sarcoma with loss of … [141] => tazemetostat in advanced epithrlioid sarcoma with loss of … [142] => tazemetostat in advanced epith4lioid sarcoma with loss of … [143] => tazemetostat in advanced epith3lioid sarcoma with loss of … [144] => tazemetostat in advanced epithekioid sarcoma with loss of … [145] => tazemetostat in advanced epithepioid sarcoma with loss of … [146] => tazemetostat in advanced epitheoioid sarcoma with loss of … [147] => tazemetostat in advanced epitheluoid sarcoma with loss of … [148] => tazemetostat in advanced epitheljoid sarcoma with loss of … [149] => tazemetostat in advanced epithelkoid sarcoma with loss of … [150] => tazemetostat in advanced epithelooid sarcoma with loss of … [151] => tazemetostat in advanced epithel9oid sarcoma with loss of … [152] => tazemetostat in advanced epithel8oid sarcoma with loss of … [153] => tazemetostat in advanced epitheliiid sarcoma with loss of … [154] => tazemetostat in advanced epithelikid sarcoma with loss of … [155] => tazemetostat in advanced epithelilid sarcoma with loss of … [156] => tazemetostat in advanced epithelipid sarcoma with loss of … [157] => tazemetostat in advanced epitheli0id sarcoma with loss of … [158] => tazemetostat in advanced epitheli9id sarcoma with loss of … [159] => tazemetostat in advanced epithelioud sarcoma with loss of … [160] => tazemetostat in advanced epitheliojd sarcoma with loss of … [161] => tazemetostat in advanced epitheliokd sarcoma with loss of … [162] => tazemetostat in advanced epitheliood sarcoma with loss of … [163] => tazemetostat in advanced epithelio9d sarcoma with loss of … [164] => tazemetostat in advanced epithelio8d sarcoma with loss of … [165] => tazemetostat in advanced epitheliois sarcoma with loss of … [166] => tazemetostat in advanced epithelioix sarcoma with loss of … [167] => tazemetostat in advanced epithelioic sarcoma with loss of … [168] => tazemetostat in advanced epithelioif sarcoma with loss of … [169] => tazemetostat in advanced epithelioir sarcoma with loss of … [170] => tazemetostat in advanced epithelioie sarcoma with loss of … [171] => tazemetostat in advanced epithelioid aarcoma with loss of … [172] => tazemetostat in advanced epithelioid zarcoma with loss of … [173] => tazemetostat in advanced epithelioid xarcoma with loss of … [174] => tazemetostat in advanced epithelioid darcoma with loss of … [175] => tazemetostat in advanced epithelioid earcoma with loss of … [176] => tazemetostat in advanced epithelioid warcoma with loss of … [177] => tazemetostat in advanced epithelioid szrcoma with loss of … [178] => tazemetostat in advanced epithelioid ssrcoma with loss of … [179] => tazemetostat in advanced epithelioid swrcoma with loss of … [180] => tazemetostat in advanced epithelioid sqrcoma with loss of … [181] => tazemetostat in advanced epithelioid saecoma with loss of … [182] => tazemetostat in advanced epithelioid sadcoma with loss of … [183] => tazemetostat in advanced epithelioid safcoma with loss of … [184] => tazemetostat in advanced epithelioid satcoma with loss of … [185] => tazemetostat in advanced epithelioid sa5coma with loss of … [186] => tazemetostat in advanced epithelioid sa4coma with loss of … [187] => tazemetostat in advanced epithelioid sarxoma with loss of … [188] => tazemetostat in advanced epithelioid sarvoma with loss of … [189] => tazemetostat in advanced epithelioid sarfoma with loss of … [190] => tazemetostat in advanced epithelioid sardoma with loss of … [191] => tazemetostat in advanced epithelioid sarcima with loss of … [192] => tazemetostat in advanced epithelioid sarckma with loss of … [193] => tazemetostat in advanced epithelioid sarclma with loss of … [194] => tazemetostat in advanced epithelioid sarcpma with loss of … [195] => tazemetostat in advanced epithelioid sarc0ma with loss of … [196] => tazemetostat in advanced epithelioid sarc9ma with loss of … [197] => tazemetostat in advanced epithelioid sarcona with loss of … [198] => tazemetostat in advanced epithelioid sarcoka with loss of … [199] => tazemetostat in advanced epithelioid sarcoja with loss of … [200] => tazemetostat in advanced epithelioid sarcomz with loss of … [201] => tazemetostat in advanced epithelioid sarcoms with loss of … [202] => tazemetostat in advanced epithelioid sarcomw with loss of … [203] => tazemetostat in advanced epithelioid sarcomq with loss of … [204] => tazemetostat in advanced epithelioid sarcoma qith loss of … [205] => tazemetostat in advanced epithelioid sarcoma aith loss of … [206] => tazemetostat in advanced epithelioid sarcoma sith loss of … [207] => tazemetostat in advanced epithelioid sarcoma eith loss of … [208] => tazemetostat in advanced epithelioid sarcoma 3ith loss of … [209] => tazemetostat in advanced epithelioid sarcoma 2ith loss of … [210] => tazemetostat in advanced epithelioid sarcoma wuth loss of … [211] => tazemetostat in advanced epithelioid sarcoma wjth loss of … [212] => tazemetostat in advanced epithelioid sarcoma wkth loss of … [213] => tazemetostat in advanced epithelioid sarcoma woth loss of … [214] => tazemetostat in advanced epithelioid sarcoma w9th loss of … [215] => tazemetostat in advanced epithelioid sarcoma w8th loss of … [216] => tazemetostat in advanced epithelioid sarcoma wirh loss of … [217] => tazemetostat in advanced epithelioid sarcoma wifh loss of … [218] => tazemetostat in advanced epithelioid sarcoma wigh loss of … [219] => tazemetostat in advanced epithelioid sarcoma wiyh loss of … [220] => tazemetostat in advanced epithelioid sarcoma wi6h loss of … [221] => tazemetostat in advanced epithelioid sarcoma wi5h loss of … [222] => tazemetostat in advanced epithelioid sarcoma witg loss of … [223] => tazemetostat in advanced epithelioid sarcoma witb loss of … [224] => tazemetostat in advanced epithelioid sarcoma witn loss of … [225] => tazemetostat in advanced epithelioid sarcoma witj loss of … [226] => tazemetostat in advanced epithelioid sarcoma witu loss of … [227] => tazemetostat in advanced epithelioid sarcoma wity loss of … [228] => tazemetostat in advanced epithelioid sarcoma with koss of … [229] => tazemetostat in advanced epithelioid sarcoma with poss of … [230] => tazemetostat in advanced epithelioid sarcoma with ooss of … [231] => tazemetostat in advanced epithelioid sarcoma with liss of … [232] => tazemetostat in advanced epithelioid sarcoma with lkss of … [233] => tazemetostat in advanced epithelioid sarcoma with llss of … [234] => tazemetostat in advanced epithelioid sarcoma with lpss of … [235] => tazemetostat in advanced epithelioid sarcoma with l0ss of … [236] => tazemetostat in advanced epithelioid sarcoma with l9ss of … [237] => tazemetostat in advanced epithelioid sarcoma with loas of … [238] => tazemetostat in advanced epithelioid sarcoma with lozs of … [239] => tazemetostat in advanced epithelioid sarcoma with loxs of … [240] => tazemetostat in advanced epithelioid sarcoma with lods of … [241] => tazemetostat in advanced epithelioid sarcoma with loes of … [242] => tazemetostat in advanced epithelioid sarcoma with lows of … [243] => tazemetostat in advanced epithelioid sarcoma with losa of … [244] => tazemetostat in advanced epithelioid sarcoma with losz of … [245] => tazemetostat in advanced epithelioid sarcoma with losx of … [246] => tazemetostat in advanced epithelioid sarcoma with losd of … [247] => tazemetostat in advanced epithelioid sarcoma with lose of … [248] => tazemetostat in advanced epithelioid sarcoma with losw of … [249] => tazemetostat in advanced epithelioid sarcoma with loss if … [250] => tazemetostat in advanced epithelioid sarcoma with loss kf … [251] => tazemetostat in advanced epithelioid sarcoma with loss lf … [252] => tazemetostat in advanced epithelioid sarcoma with loss pf … [253] => tazemetostat in advanced epithelioid sarcoma with loss 0f … [254] => tazemetostat in advanced epithelioid sarcoma with loss 9f … [255] => tazemetostat in advanced epithelioid sarcoma with loss od … [256] => tazemetostat in advanced epithelioid sarcoma with loss oc … [257] => tazemetostat in advanced epithelioid sarcoma with loss ov … [258] => tazemetostat in advanced epithelioid sarcoma with loss og … [259] => tazemetostat in advanced epithelioid sarcoma with loss ot … [260] => tazemetostat in advanced epithelioid sarcoma with loss or … 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