Triple response of Lewis – Wikipedia

January 15, 2021

The underlying pathophysiology of frostbite is a combination of freezing, vascular insufficiency (constriction and occlusion) and damage due to inflammatory mediators. As extremities cool, the ‘hunting response of Lewis’ (alternating vasoconstriction and vasodilation) occurs, ending with vasoconstriction.

https://en.wikipedia.org/wiki/Triple_response_of_Lewis

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