YubiKey security keys use Universal 2nd Factor (U2F), an open authentication standard that enables users to easily and securely access multiple online services using a single security key, without needing to install drivers or client software. AWS allows you to enable a YubiKey security key as the MFA device for your IAM users.
https://aws.amazon.com/blogs/security/use-yubikey-security-key-sign-into-aws-management-console/